KN-92 hydrochloride

CAS No. 1431698-47-3

KN-92 hydrochloride( —— )

Catalog No. M22113 CAS No. 1431698-47-3

KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM binding to the kinase with Ki of 370 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 82 In Stock
5MG 164 In Stock
10MG 246 In Stock
25MG 447 In Stock
50MG 651 In Stock
100MG 888 In Stock
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Biological Information

  • Product Name
    KN-92 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM binding to the kinase with Ki of 370 nM.
  • Description
    KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM binding to the kinase with Ki of 370 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    CaMK
  • Recptor
    CaMKII
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1431698-47-3
  • Formula Weight
    493.45
  • Molecular Formula
    C24H26Cl2N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:40 mg/mL (81.06 mM)
  • SMILES
    Cl.COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CN(C)C\C=C\c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rezazadeh S, Claydon TW, Fedida D. et al. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J Pharmacol Exp Ther. 2006 Apr;317(1):292-9.
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